MicroRNA‑448 modulates the progression of neuropathic pain by targeting sirtuin 1
نویسندگان
چکیده
منابع مشابه
Immunotherapy targeting cytokines in neuropathic pain
Pain is a complex warning system activated in response to potential or apparent danger and the absence of pain is detrimental. Nociceptive pain is high-threshold pain activated in the presence of intense stimuli, such as contact with a burning object, and is a protective system essential for detection of noxious stimuli. Inflammatory pain, caused by immune system activation in response to tissu...
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Neuropathic pain is caused by dysfunction or primary injury of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) play important roles in the development of neuropathic pain. However, the effects of lncRNA colon cancer associated transcript-1 (CCAT1) in neuropathic pain have not been reported. The model of bilateral sciatic nerve chronic constriction injuries (bCCI) is regarded as ...
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15 صفحه اولMiR-19a targets suppressor of cytokine signaling 1 to modulate the progression of neuropathic pain.
PURPOSE We aimed to investigate whether miR-19a is associated with neuropathic pain and elucidate the underlying regulatory mechanism. METHODS We established a neuropathic pain model of bilateral chronic constriction injury (bCCI). Then bCCI rats were injected with mo-miR-19a, siR-SOCS1 or blank expression vector through a microinjection syringe via an intrathecal catheter on 3 day before sur...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2019
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2019.8165